A 56-day double-blind clinical trial by Senye-Zhongyan-Youke confirms that plant-derived C. asiatica EVs combined with rIGF-1 & rFGF-7 growth factors reduce daily hair loss by 63.6% and increase hair density by 23.9%. Science-backed, non-pharmaceutical hair care.
Introduction: A Science-Backed Answer to Hair Loss
Hair loss affects hundreds of millions of people worldwide, impacting confidence and quality of life. Senye-Zhongyan-Youke developed a biotech-driven scalp serum combining Centella asiatica Extracellular Vesicles (C. asiatica EVs) with long-acting Recombinant Growth Factors (rIGF-1 and rFGF-7), validated in a 56-day randomized, double-blind, placebo-controlled clinical trial (ClinicalTrials.gov: NCT06985121).
How This Formula Works
1. C. asiatica EVs — Plant-Derived Nanocarriers
Derived from Centella asiatica (Gotu Kola), these EVs penetrate deeply into the scalp to:
- Reduce scalp inflammation — a key driver of follicle miniaturization
- Regulate excess sebum production
- Activate dermal papilla cells to initiate and sustain hair growth
2. Recombinant Growth Factors: rIGF-1 & rFGF-7
Engineered with Fc-fusion technology for extended biological half-life, these growth factors:
- Prolong the anagen (growth) phase of the hair cycle
- Prevent premature follicle entry into the catagen (regression) phase
- Stimulate hair shaft thickening and structural integrity
Clinical Trial Design
| Parameter | Details |
|---|---|
| Duration | 56 days |
| Design | Randomized, Double-Blind, Placebo-Controlled |
| Registration | NCT06985121 |
| Institution | Senye-Zhongyan-Youke |
| Test Group | Group E — Full Formula |
Day 56 Results (Group E — Full Formula)
Scalp Sebum Control: −59%
Restores a balanced scalp microenvironment, reducing conditions that accelerate follicle damage.
Hair Length Growth: +3.5 cm
Statistically significant growth differences observed from Day 14 onward.
Hair Diameter (Thickness): +27.9 μm
Thicker hair shafts mean visibly fuller, more resilient hair with reduced breakage.
Hair Density: +23.9%
Measurable increase in follicular unit count per area — significant improvement in overall volume.
Daily Hair Loss: −63.6%
The standout result: nearly two-thirds fewer hairs shed per day compared to baseline.
Conclusion
The combination of plant-derived EVs and long-acting recombinant growth factors delivers a synergistic, multi-target effect — addressing sebum control, growth stimulation, density, and hair loss simultaneously. A safe, effective, science-backed non-pharmaceutical solution for hair and scalp rejuvenation.
About Senye-Zhongyan-Youke
A biotech-driven cosmetic research institution developing clinically validated, plant-science solutions for scalp and hair health.
Senye-Zhongyan-Youke Research Team
Biotech Cosmetic Research Institution
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